Time Trends of Peptic Ulcer Diagnosis as Compared to Gastric Carcinoma and Chronic Gastritis in an Endoscopic Population

Simona Valean1, Marcel Tantau2, Adina Lariu1, Magda Petrescu3, Corneliu D Olinici3, Andrei Ban2, Sorin Pop1, Petru A. Mircea1, Oliviu Pascu2

1) 1st Medical Clinic. 2) 3rdMedical Clinic. 3) Department of Pathology, University of Medicine and Pharmacy Cluj-Napoca

Abstract

The aim of the study was to assess the time trends of the diagnosis of peptic ulcer as compared to gastric cancer and chronic gastritis in an endoscopic population, 1995 versus 1985. The diagnosis of gastric cancer was analysed also in relation to the frequency of some of the preneoplasic conditions and lesions of the stomach, like atrophic gastritis, intestinal metaplasia, dysplasia, adenomatous polyp and gastric remnant.
The 1985 series included 1431 patients, 324 with duodenal ulcer (DU), 301 with gastric ulcer (GU), 159 with gastric cancer, 574 with chronic gastritis, 16 with adenomatous polyp/polyps and 57 with gastric remnant. The 1995 series included 1390 patients, 254 with DU, 253 with GU, 214 with gastric cancer, 638 with chronic gastritis, 22 with adenomatous polyps and 9 with gastric remnant.
In our endoscopic population a significant decrease of DU and GU was recorded in 1995 as compared with 1985. DU/GU ratio was low in both series, 1.07/1 and 1/1, respectively. Mean age of patients with peptic ulcer diasease was significantly higher in 1995 (45.3 versus 40.2 years). Sex ratio showed a male predominance of DU (2.5/1) and GU (1.8/1). In the same period, a significant increase of gastric cancer and chronic gastritis diagnosis was recorded. Atrophic gastritis appeared to be the most significant risk factor for gastric cancer in our population, since gastric remnant was significantly more rarely recorded in 1995 and an adenomatous polyp was a rare finding in both our series of patients.