Acute Pancreatitis, Acute Hepatitis and Acute Renal Failure Favourably Resolved in Two Renal Transplant Recipients

Mihai Voiculescu1, Camelia Ionescu1, Gener Ismail1, Eugen Mandache2, Monica Hortopan3, Ileana Constantinescu1, Olguta Iliescu1

1) Department of Internal Medicine - Nephrology, “Fundeni” Institute. 2) Department of Pathology, “V. Babes” Institute.

3) Department of Pathology and 4) Virusology, “Fundeni” Institute, Bucharest

Abstract

Renal transplantation is often associated with severe complications. Except for acute rejection, infections and toxicity of immunosuppressive treatment are the most frequent problems observed after transplantation. Infections with hepatic viruses (HBV, HDV, HCV, HGV) and cytomegalic virus (CMV) are the main infectious complications after renal transplantation. Cyclosporine toxicity is not unusual for a patient with renal transplantation and is even more frequent for patients with hepatic impairment due to viral infections. The subjects of this report are two renal transplant recipients with acute pancreatitis, severe hepatitis and acute renal failure on graft, receving immunosuppressive therapy for maintaining renal graft function.

Key words

Renal transplantation - acute pancreatitis - acute viral hepatitis - cyclosporine nephrotoxicity - acute renal failure