phosphorylase expression in patients with chronic viral hepatitis
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E.Sivridis, V.Papadopoulos, K.Ritis, G.Kartalis
1) First Department of Internal
Medicine. 2) Department of Pathology, Democritus University
of Thrace,Alexandroupolis, Greece
The role of thymidine phosphorylase (TP), an angiogenic factor,
in chronic viral hepatitis is unclear. In the present study
we investigated TP expression in chronic viral hepatitis due
to hepatitis B virus (HBV) and hepatitis C virus (HCV) infection.
Fifty-eight patients suffering from chronic viral hepatitis
and 13 cirrhotic patients due to either HBV or HCV were studied.
TP expression was investigated using a standard immunohistochemical
technique and the specific antibody P-GF.44C.
The pattern of TP staining was predominantly nuclear, or mixed
nuclear/cytoplasmic, but no significant difference in such expression
was noted between chronic hepatitis B and C: nuclear immunostaining,
t=0.0616, p=0.9511; cytoplasmic immunostaining, t=0.5188, p=0.6060.
There was, however, a marked difference in TP expression between
patients with chronic hepatitis B/C and cirrhosis. Notably,
this finding applied to both nuclear (p=0.00754, p=0.0143, respectively)
and cytoplasmic (p=0.000091, p=0.000031, respectively) expression.
These observations indicate that TP expres-sion, although linked
to liver cirrhosis, may not be virus-related.
- chronic viral hepatitis - cirrhosis