Confocal Endomicroscopy for in vivo Microscopic Analysis of Upper Gastrointestinal Tract Premalignant and Malignant Lesions

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Cristian Gheorghe, Razvan Iacob, Gabriel Becheanu, Mona Dumbrava

Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania


Confocal LASER endomicroscopy (CLE) is a new endoscopic technique which allows subsurface in vivo microscopic analysis during ongoing endoscopy, using systemically or topically administered fluorescent agents. It allows targeted biopsies to be taken, potentially improving the diagnostic rate in certain gastrointestinal diseases. Worldwide experience with CLE for upper gastrointestinal malignant and premalignant lesions is still reduced. Potential clinical aplications are presented, including diagnosis of NERD, Barrett's esophagus, atrophic gatritis, gastric intestinal metaplasia and dysplasia, gastric adenomatous or hyperplastic polyps, gastric cancer.

Key words
Confocal LASER endomicroscopy - malignant/premalignant digestive lesions