Treatment with Interferon Alpha and Peginterferon Induces Rheumatoid
Artrhitis Syndrome and Erythema Nodosum
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Camelia Ionescu1, Laurenşiu Micu1, Ileana
Constantinescu2, Monica Hortopan3, Cornel
Ursaciuc4, Mihai Voiculescu1
1) Department of Internal Medicine - Nephrology;
2) Immunology and Virology Laboratory;
3) Pathology Laboratory, "Fundeni" Clinical Institute,
4) Immunology Laboratory, "V. Babes" Institute, Bucharest,
The antiviral treatment of chronic C hepatitis has improved significantly
over the past decade with the introduction of interferons (IFNs),
and more recently, pegylated IFNs. Up to two-thirds of all patients
treated with pegylated IFN combined with ribavirin can now achieve
viral eradication if treated according to current guidelines.
Despite this success rate, hematological, immunological, rheumatological
and dermatological side effects have been reported in chronic
hepatitis C patients treated with IFN-alpha. The subjects of this
report are two young females with chronic hepatitis C, who developed
rheumatoid syndrome and/or erithema nodosum during antiviral treatment
with IFN-alpha or pegylated IFN combined with ribavirine.
Interferon alpha - peginterferon - chronic hepatitis C - rheumatoid
arthritis syndrome - erythema nodosum.