Esophageal Xanthoma - Report of Two New Cases and Review of the Literature

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Gabriel Becheanu1, Mona Dumbrava1, Tudor Arbanas1, Mircea Diculescu1, Nadia Hoyeau-Idrissi2, Jean-François Fléjou2

1) Gastroenterology and Hepatology Department, Fundeni Clinical Institute, Bucharest, Romania;
2) Pathology Department, Saint-Antoine Hospital, Paris, France


Background: Esophageal xanthoma is a very rare lesion which can be incidentally discovered during endoscopy. Only eleven cases have been reported, including ours.

Case reports: We present two new cases of esophageal xanthoma localized in the lower esophagus in a 56-year-old woman and a 62-year-old man. Endoscopically, esophageal xanthoma appears as yellowish granular spots or a slightly elevated lesion. Microscopically, it consists of fat accumulation in foamy histiocytes beneath the squamous epithelium.

Conclusions: The clinical and pathological importance of these lesions and what they mean in patients is discussed, along with a review of the literature.

Key words
Esophagus - xanthoma - foamy macrophages - immunohistochemistry.