Crohn's Disease Complicated by Primary Gastrointestinal Hodgkin's Lymphoma Presenting with Small Bowel Perforation
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Aurelio Castrellon1, Paul Andrew Feldman2, Miguel Suarez3, Seth Spector3, Lucy Chua3, John Byrnes3
1) University of Miami;
2) Miami Veteran Administration Medical Center;
3) Miami Veteran Administration Hospital, Miami, FL, USA
Abstract
An increased incidence of non-Hodgkin's lymphoma has been reported in patients with inflammatory bowel disease, particularly in those receiving immunosuppressive therapy. Rare cases of Hodgkin`s lymphoma have been reported in a setting of inflammatory bowel disease. The mechanism underlying the apparent association is unclear, but alterations in immune surveillance could play a role. In this report we describe the clinicopathological features of primary gastrointestinal Hodgkin's lymphoma diagnosed in a patient with Crohn's ileocolitis who had been receiving therapy with immunomodulator and biologic therapies.
Key words
Crohn's disease - Hodgkin's lymphoma - immunomodulators - anti-TNF therapy.
