CASE REPORTS

Primary Squamous Cell Carcinoma of the Liver

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Seeta Naik1, Waris Waris1, Linda Carmosino1, Anshu Mehrishi1, Muhammad Wasif Saif2

1) Department of Hematology-Oncology, Nassau University Medical Center, NY;
2) Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA

Abstract

Primary squamous cell carcinoma (SCC) of the liver is rare. Totally twenty-two such cases have been reported in the literature. Primary SCC of the liver has been reported to be associated with hepatic teratoma, hepatic cyst, or hepatolithiasis. We present the first case of SCC of the liver with no history of prior liver insult, a parasitic infection or pre-existing hepatic cysts.  In general, the prognosis of primary SCC of the liver is dismal with overall survival less than one year, but our patient who was treated initially with radiation and later by surgical resection has no evidence of disease recurrence over 6 years.

Key words

Squamous cell carcinoma - liver - surgery - cisplatin - 5-FU - cetuximab - erlotinib.