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Article 19, 3/2016

REVIEW

Magnetic Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy

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Bogdan Silviu Ungureanu1, Cristian-Mihail Teodorescu2, Adrian Săftoiu1,3

1) Research Center of Gastroenterology and Hepatology of Craiova, Craiova, Romania
2) National Institute of Material Physics, Magurele, Romania
3) Department of Endoscopy, Gastrointestinal Unit, Copenhagen University Herlev Hospital Copenhagen, Denmark

DOI: http://dx.doi.org/10.15403/jgld.2014.1121.253.nan

ABSTRACT
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver, ranking as the second most common cause of death from cancer worldwide. Magnetic nanoparticles (MNPs) have been used so far in tumor diagnosis and treatment, demonstrating great potential and promising results. In principle, three different approaches can be used in the treatment of tumors with superparamagnetic iron oxide nanoparticles: magnetically induced hyperthermia, drug targeting and selective suppression of tumor growth. This review focuses on the use of iron oxide nanoparticles for the diagnosis and treatment of liver cancer and offers a walkthrough from the MNPs imaging applicability to further therapeutic options, including their potential flaws. The MNP unique physical and biochemical properties will be mentioned in close relationship to their subsequent effects on the human body, and, also, their toxic potential will be noted. A presentation of what barriers the MNPs should overcome to be more successful will conclude this review.

Key words: magnetic nanoparticles – hepatocellular carcinoma – diagnosis – therapy.

Abbreviations: AMF: Alternating magnetic field; DOX: Doxorubicin; GD: Gadolinium; HCC: hepatocellular carcinoma; 131I: Iodine 131; MDT: Magnetic drug targeting; ML: Magnetoliposomes; MNP: magnetic nanoparticles; MRI: Magnetic Resonance Imaging; PNIPA: Poly-N-isopropylacrylamide; SPIONS: Superparamagnetic iron oxide nanoparticles; VEGF: Vascular endothelial growth factor.