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Article 13, 4/2018


Nonalcoholic Fatty Liver Disease and Urolithiasis. A Systematic Review and Meta-Analysis
Karn Wijarnpreecha1,2, Susan Lou3, Panadeekarn Panjawatanan4, Anawin Sanguankeo5,6, Surakit Pungpapong2, Frank J. Lukens2, Patompong Ungprasert7*

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1) Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA
2) Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida, USA
3) Department of Medicine, University of Minnesota, Minneapolis, MN, USA
4) Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
5) Divison of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
6) Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
7) Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

DOI: http://dx.doi.org/10.15403/jgld.2014.1121.274.nac


Background & Aims: Recent studies have suggested that nonalcoholic fatty liver disease (NAFLD) could be a predisposing factor for urolithiasis but the results have been inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data.
Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through March 2018 to identify all studies that compared the risk of urolithiasis among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird.
Results: A total of eight studies with 238,400 participants fulfilled the eligibility criteria and were included in the meta-analysis. The risk of urolithiasis among patients with NAFLD was significantly higher than in those without NAFLD with a pooled odds ratio of 1.81 (95% confidence interval, 1.29-2.56; I2 92%).
Conclusions: A significantly increased risk of urolithiasis among patients with NAFLD was observed in this meta-analysis.
Key words: Nonalcoholic fatty liver disease – nonalcoholic steatohepatitis – urolithiasis – kidney stone – meta-analysis.
Abbreviations: CT: computer tomography; NAFLD: nonalcoholic fatty liver disease.