Gangliocytic Paraganglioma: a Rare Cause of Gastrointestinal Bleeding
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Alina Boeriu1, Daniela Dobru1, Rares Georgescu2, Simona Mocan3, Cristian Boeriu4
1) Department of Gastroenterology;
2) Department of Surgery, University of Medicine and Pharmacy Tīrgu Mures;
3) Department of Pathology, Tīrgu Mures County Emergency Hospital;
4) Emergency Department, University of Medicine and Pharmacy, Tārgu Mures
Duodenal neuroendocrine tumors (NETs) are rare tumors, consisting of five different types of tumors. In many cases, they may be asymptomatic, leading to delay in diagnosis. Clinical symptoms are related to local tumor growth and mucosal ulceration. We report a 38-year old man with duodenal gangliocytic paraganglioma causing overt upper gastrointestinal bleeding and anemia. We describe specific clinical and histopathological features of the tumor, and review the diagnostic and therapeutic strategy. Gangliocytic paragangliomas are regarded as benign tumors. However, the disease recurrence and the malignant potential of the tumor have also been reported.
Key words: gangliocytic paraganglioma - immunostaining - surgical excision - metastasis.