Pancreatic Cancer: Multicenter Prospective Data Collection and Analysis by the Hungarian Pancreatic Study Group

Authors

  • Gábor Lakatos Dept. Oncology, St. Istvan and St. Laszlo Hospital and Out- Patient Department, Budapest, Hungary
  • Anita Balázs 1st Dept. Medicine, University of Szeged, Hungary
  • Balázs Kui 1st Dept. Medicine, University of Szeged, Hungary
  • Szilárd Gódi 1st Dept. Medicine, University of Pécs, Hungary
  • Ákos Szücs 1st Dept. Surgery, Semmelweis University, Budapest, Hungary
  • Andrea Szentesi 1st Dept. Medicine, University of Szeged, Hungary
  • Zsolt Szentkereszty Institute of Surgery, Clinical Center, University of Debrecen, Hungary
  • Richárd Szmola Dept. Interventional Gastroenterology, National Institute of Oncology, Budapest, Hungary
  • Dezső Kelemen Dept. Surgery, University of Pécs, Hungary
  • Róbert Papp Dept. Surgery, University of Pécs, Hungary
  • Áron Vincze 1st Dept. Medicine, University of Pécs, Hungary
  • József Czimmer 1st Dept. Medicine, University of Pécs, Hungary
  • Gabriella Pár 1st Dept. Medicine, University of Pécs, Hungary
  • Judit Bajor 1st Dept. Medicine, University of Pécs, Hungary
  • Imre Szabó 1st Dept. Medicine, University of Pécs, Hungary
  • Ferenc Izbéki 1st Dept. Medicine, Szent György University Teaching Hospital of County Fejér, Székesfehérvár, Hungary
  • Adrienn Halász 1st Dept. Medicine, Szent György University Teaching Hospital of County Fejér, Székesfehérvár, Hungary
  • László Leindler Dept. Surgery, University of Szeged, Hungary
  • Gyula Farkas Jr. Dept. Surgery, University of Szeged, Hungary
  • Tamás Takács 1st Dept. Medicine, University of Szeged, Hungary
  • László Czakó 1st Dept. Medicine, University of Szeged, Hungary
  • Zoltán Szepes 1st Dept. Medicine, University of Szeged, Hungary
  • Péter Hegyi 1st Dept. Medicine, University of Szeged ; Hungarian Academy of Sciences, University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group ; Institute for Translational Medicine & 1st Department of Medicine, University of Pécs; 12) Dept. Oncotherapy, University of Szeged, Hungary
  • Zsuzsanna Kahán Dept. Oncotherapy, University of Szeged, Hungary

DOI:

https://doi.org/10.15403/jgld.2014.1121.252.pcr

Keywords:

pancreatic cancer, Hungarian cohort, acute pancreatitis, chronic pancreatitis, diabetes mellitus

Abstract

Background & Aims: Pancreatic cancer is a devastating disease with poor prognosis. There is very limited information available regarding the epidemiology and treatment strategies of pancreatic cancer in Central Europe. The purpose of the study was to prospectively collect and analyze data of pancreatic cancer in the Hungarian population.

Methods: The Hungarian Pancreatic Study Group (HPSG) organized prospective, uniform data collection. Altogether 354 patients were enrolled from 14 Hungarian centers.

Results: Chronic pancreatitis was present in 3.7% of the cases, while 33.7% of the patients had diabetes. Family history for pancreatic cancer was positive in 4.8%. The most frequent presenting symptoms included pain (63.8%), weight loss (63%) and jaundice (52.5%). The reported frequency of smoking and alcohol consumption was lower than expected (28.5% and 27.4%, respectively). The majority of patients (75.6%) were diagnosed with advanced disease. Most patients (83.6%) had a primary tumor located in the pancreatic head. The histological diagnosis was ductal adenocarcinoma in 90.7% of the cases, while neuroendocrine tumor was present in 5.3%. Biliary stent implantation was performed in 166 patients, 59.2% of them received metal stents. Primary tumor resection was performed in 60 (16.9%) patients. Enteral or biliary bypass was done in 35 and 49 patients, respectively. In a multivariate Cox-regression model, smoking status and presence of gemcitabine-based chemotherapy were identified as independent predictors for overall survival.

Conclusion: We report the first data from a large cohort of Hungarian pancreatic cancer patients. We identified smoking status and chemotherapy as independent predictors in this cohort.

Abbreviations: EBM: evidence-based medicine; EPI: exocrine pancreatic insufficiency; FNAB: fine needle aspiration biopsy; HPSG: Hungarian Pancreatic Study Group; MDCT: multi-detector computed tomography; OS: overall survival; PC: pancreatic cancer; RPP: Registry for Pancreatic Patients

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Published

2016-06-01

How to Cite

1.
Lakatos G, Balázs A, Kui B, Gódi S, Szücs Ákos, Szentesi A, Szentkereszty Z, Szmola R, Kelemen D, Papp R, Vincze Áron, Czimmer J, Pár G, Bajor J, Szabó I, Izbéki F, Halász A, Leindler L, Farkas Jr. G, Takács T, Czakó L, Szepes Z, Hegyi P, Kahán Z. Pancreatic Cancer: Multicenter Prospective Data Collection and Analysis by the Hungarian Pancreatic Study Group. JGLD [Internet]. 2016 Jun. 1 [cited 2026 Apr. 14];25(2):219-25. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/1110

Issue

Vol. 25 No. 2: June 2016

Section

Original Article