Health-related Quality of Life and Utilities in Gastric Premalignant Conditions and Malignant Lesions: a Multicentre Study in a High Prevalence Country

Authors

  • Miguel Areia Center for Research in Health Technologies and Information Systems, Faculty of Medicine, Porto University; Gastroenterology Dept., Portuguese Oncology Institute of Coimbra, Portugal
  • Susana Alves Gastroenterology Dept., Portuguese Oncology Institute of Coimbra, Portugal
  • Daniel Brito Gastroenterology Dept., Portuguese Oncology Institute of Coimbra, Portugal
  • Ana Teresa Cadime Gastroenterology Dept., Portuguese Oncology Institute of Coimbra, Portugal
  • Rita Carvalho Gastroenterology Dept., Portuguese Oncology Institute of Coimbra, Portugal
  • Sandra Saraiva Gastroenterology Dept., Portuguese Oncology Institute of Coimbra, Portugal
  • Sara Ferreira Gastroenterology Dept., Portuguese Oncology Institute of Lisbon, Portugal
  • Joana Moleiro Gastroenterology Dept., Portuguese Oncology Institute of Lisbon, Portugal
  • António Dias Pereira Gastroenterology Dept., Portuguese Oncology Institute of Lisbon, Portugal
  • João Carrasquinho Gastroenterology Dept., Santa Luzia Hospital - Viana do Castelo (Local Health Unit of Alto Minho), Portugal
  • Luís Lopes Gastroenterology Dept., Santa Luzia Hospital - Viana do Castelo (Local Health Unit of Alto Minho), Portugal
  • José Ramada Gastroenterology Dept., Santa Luzia Hospital - Viana do Castelo (Local Health Unit of Alto Minho), Portugal
  • Ricardo Marcos-Pinto Center for Research in Health Technologies and Information Systems, Faculty of Medicine, Porto University; Gastroenterology Dept., Santo António General Hospital, Hospital Centre of Porto; Institute of Biomedical Sciences Abel Salazar,University of Portom Portugal
  • Isabel Pedroto Gastroenterology Dept., Santo António General Hospital, Hospital Centre of Porto; Institute of Biomedical Sciences Abel Salazar,University of Porto, Portugal
  • Luís Contente Gastroenterology Dept., Hospital Unit of Portimão (Hospital Center of Western Algarve), Portugal
  • Liliana Eliseu Gastroenterology Dept., Hospital Unit of Portimão (Hospital Center of Western Algarve), Portugal
  • Ana Margarida Vieira Gastroenterology Dept., Hospital Unit of Portimão (Hospital Center of Western Algarve), Portugal
  • Margarida Sampaio Gastroenterology Dept., Hospital Unit of Portimão (Hospital Center of Western Algarve), Portugal
  • Helena Tavares Sousa Gastroenterology Dept., Hospital Unit of Portimão (Hospital Center of Western Algarve), Portugal
  • Nuno Almeida Gastroenterology Dept., Coimbra University Hospital Center, Coimbra, Portugal
  • Carlos Gregório Gastroenterology Dept., Coimbra University Hospital Center, Coimbra, Portugal
  • Francisco Portela Gastroenterology Dept., Coimbra University Hospital Center, Coimbra, Portugal
  • Carlos Sofia Gastroenterology Dept., Coimbra University Hospital Center, Coimbra, Portugal
  • Vânia Braga Gastroenterology Dept., Portuguese Oncology Institute of Porto, Porto, Portugal
  • Elisabete Baginha Gastroenterology Dept., West Lisbon Hospital Centre, Lisbon, Portugal
  • Tiago Bana e Costa Gastroenterology Dept., West Lisbon Hospital Centre, Lisbon, Portugal
  • Cristina Chagas Gastroenterology Dept., West Lisbon Hospital Centre, Lisbon, Portugal
  • Luís Lebre Mendes Gastroenterology Dept., West Lisbon Hospital Centre, Lisbon, Portugal
  • Pedro Magalhães-Costa Gastroenterology Dept., West Lisbon Hospital Centre, Lisbon, Portugal
  • Leopoldo Matos Gastroenterology Dept., West Lisbon Hospital Centre, Lisbon, Portugal
  • Francisco Rocha Gonçalves Center for Research in Health Technologies and Information Systems, Faculty of Medicine, Porto University; Gastroenterology Dept., Portuguese Oncology Institute of Porto, Portugal
  • Mário Dinis-Ribeiro Center for Research in Health Technologies and Information Systems, Faculty of Medicine, Porto University; Gastroenterology Dept., Portuguese Oncology Institute of Porto, Portugal

DOI:

https://doi.org/10.15403/jgld.2014.1121.234.hrq

Keywords:

gastrointestinal endoscopy, QoL, gastric cancer, intestinal metaplasia, atrophic gastritis

Abstract

Background & Aims: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument.

Methods: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire.

Results: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70).

Conclusion: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis.

Abbreviations: LYS: life-years saved; QALY: quality-adjusted life years; VAS: visual analogue scale; CI: confidence interval.

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Published

2014-12-01

How to Cite

1.
Areia M, Alves S, Brito D, Cadime AT, Carvalho R, Saraiva S, Ferreira S, Moleiro J, Pereira AD, Carrasquinho J, Lopes L, Ramada J, Marcos-Pinto R, Pedroto I, Contente L, Eliseu L, Vieira AM, Sampaio M, Sousa HT, Almeida N, Gregório C, Portela F, Sofia C, Braga V, Baginha E, e Costa TB, Chagas C, Mendes LL, Magalhães-Costa P, Matos L, Gonçalves FR, Dinis-Ribeiro M. Health-related Quality of Life and Utilities in Gastric Premalignant Conditions and Malignant Lesions: a Multicentre Study in a High Prevalence Country. JGLD [Internet]. 2014 Dec. 1 [cited 2025 Jun. 9];23(4):371-8. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/1355

Issue

Vol. 23 No. 4: December 2014

Section

Original Article