Nonalcoholic Fatty Liver Disease and Urolithiasis. A Systematic Review and Meta-Analysis

Authors

  • Karn Wijarnpreecha Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida, USA
  • Susan Lou Department of Medicine, University of Minnesota, Minneapolis, MN, USA
  • Panadeekarn Panjawatanan Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • Anawin Sanguankeo Divison of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Surakit Pungpapong Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida, USA
  • Frank J Lukens Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida, USA
  • Patompong Ungprasert Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Patompong Ungprasert Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

DOI:

https://doi.org/10.15403/10.15403/jgld.2014.1121.274.nac

Keywords:

Nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, urolithiasis, kidney stone, meta-analysis

Abstract

Background & Aims: Recent studies have suggested that nonalcoholic fatty liver disease (NAFLD) could be a predisposing factor for urolithiasis but the results have been inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data.
Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through March 2018 to identify all studies that compared the risk of urolithiasis among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird.
Results: A total of eight studies with 238,400 participants fulfilled the eligibility criteria and were included in the meta-analysis. The risk of urolithiasis among patients with NAFLD was significantly higher than in those without NAFLD with a pooled odds ratio of 1.81 (95% confidence interval, 1.29-2.56; I2 92%).
Conclusions: A significantly increased risk of urolithiasis among patients with NAFLD was observed in this meta-analysis.

December 2018, volume 27, issue 4

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Published

2018-12-31

How to Cite

1.
Wijarnpreecha K, Lou S, Panjawatanan P, Sanguankeo A, Pungpapong S, Lukens FJ, Ungprasert P, Ungprasert P. Nonalcoholic Fatty Liver Disease and Urolithiasis. A Systematic Review and Meta-Analysis. JGLD [Internet]. 2018 Dec. 31 [cited 2026 Jul. 18];27(4):427-32. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/16

Issue

Vol. 27 No. 4: December 2018

Section

Systematic Review and Meta-Analysis