CccDNA Persistence During Natural Evolution of Chronic VHB Infection

Authors

  • Florin Alexandru Cãruntu Infectious Diseases Clinic “Prof.dr.Matei Bals”, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • Violeta Molagic Infectious Diseases Clinic “Prof.dr.Matei Bals”, Bucharest, Romania

Keywords:

cccDNA, hepatitis B virus, natural history, chronic viral B hepatitis

Abstract

HBV infection remains a public health issue. CccDNA – HBV is a unique, intermediate replicative episome, responsible for persistence of infection in hepatocytes. The clearance of cccDNA may be explained by cellular death. CccDNA detection in chronic infected human livers may represent an important marker in monitoring antiviral therapy. Short term therapy is followed by viral rebound in the majority of chronic HBV hepatitis patients. Based on mathematical models, it is considered that the period needed to achieve a complete intrahepatic cccDNA clearance is 14.5 years.

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Published

2005-12-01

How to Cite

1.
Cãruntu FA, Molagic V. CccDNA Persistence During Natural Evolution of Chronic VHB Infection. JGLD [Internet]. 2005 Dec. 1 [cited 2026 Jul. 17];14(4):373-7. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/2005.4.8

Issue

Vol. 14 No. 4: December 2005

Section

Reviews