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Affiliations
Camelia Ionescu
Department of Internal Medicine - Nephrology, "Fundeni" Clinical Institute, Bucharest, Romania
Laurenţiu Micu
Department of Internal Medicine - Nephrology, "Fundeni" Clinical Institute, Bucharest, Romania
Ileana Constantinescu
Immunology and Virology Laboratory, "Fundeni" Clinical Institute, Bucharest, Romania
Monica Hortopan
Pathology Laboratory, "Fundeni" Clinical Institute, Bucharest, Romania
Cornel Ursaciuc
Immunology Laboratory, “V. Babes” Institute, Bucharest, Romania
Mihai Voiculescu
Department of Internal Medicine - Nephrology, "Fundeni" Clinical Institute, Bucharest, Romania
How to Cite
Prolonged Treatment with Interferon Alpha and Peginterferon Induces Rheumatoid Artrhitis Syndrome and Erythema Nodosum
- Camelia Ionescu ,
- Laurenţiu Micu ,
- Ileana Constantinescu ,
- Monica Hortopan ,
- Cornel Ursaciuc ,
- Mihai Voiculescu
Vol 17 No 2: June 2008
Section: Case Reports
Pages: 211-212
Abstract
The antiviral treatment of chronic C hepatitis has improved significantly over the past decade with the introduction of interferons (IFNs), and more recently, pegylated IFNs. Up to two-thirds of all patients treated with pegylated IFN combined with ribavirin can now achieve viral eradication if treated according to current guidelines. Despite this success rate, hematological, immunological, rheumatological and dermatological side effects have been reported in chronic hepatitis C patients treated with IFN-alpha. The subjects of this report are two young females with chronic hepatitis C, who developed rheumatoid syndrome and/or erithema nodosum during antiviral treatment with IFN-alpha or pegylated IFN combined with ribavirine.