Primary squamous cell carcinoma (SCC) of the liver is rare. Totally twenty-two such cases have been reported in the literature. Primary SCC of the liver has been reported to be associated with hepatic teratoma, hepatic cyst, or hepatolithiasis. We present the first case of SCC of the liver with no history of prior liver insult, a parasitic infection or pre-existing hepatic cysts.  In general, the prognosis of primary SCC of the liver is dismal with overall survival less than one year, but our patient who was treated initially with radiation and later by surgical resection has no evidence of disease recurrence over 6 years.


Squamous cell carcinoma, liver, surgery, cisplatin, 5-FU, cetuximab, erlotinib