Performance of Routine Helicobacter pylori Tests in Patients with Atrophic Gastritis

Authors

  • Agnese Sudraba University of Latvia, Faculty of Medicine, Riga; ; Riga East University Hospital, Riga, Latvia
  • Ilva Daugule University of Latvia, Faculty of Medicine, Riga, Latvia
  • Dace Rudzite University of Latvia, Faculty of Medicine, Riga; ; Riga East University Hospital, Riga, Latvi
  • Konrads Funka University of Latvia, Faculty of Medicine, Riga, Latvia
  • Ivars Tolmanis Digestive Diseases Centre GASTRO, Riga, Latvia
  • Lars Engstrand Swedish Institute for Infectious Disease Control, Stockholm, Sweden
  • Dainius Janciauskas Lithuanian University of Health Sciences, Faculty of Medicine, Kaunas, Lithuania
  • Laimas Jonaitis Lithuanian University of Health Sciences, Faculty of Medicine, Kaunas, Lithuania
  • Gediminas Kiudelis Lithuanian University of Health Sciences, Faculty of Medicine, Kaunas, Lithuania
  • Limas Kupcinskas Lithuanian University of Health Sciences, Faculty of Medicine, Kaunas, Lithuania
  • Audrius Ivanauskas Lithuanian University of Health Sciences, Faculty of Medicine, Kaunas, Lithuania
  • Marcis Leja University of Latvia, Faculty of Medicine, Riga; Riga East University Hospital, Riga; Digestive Diseases Centre GASTRO, Riga, Latvia

Keywords:

Atrophic gastritis, Helicobacter pylori, rapid urease test, 13C urease breath test, histology, culture, serology

Abstract

Background. Decreased density of H.pylori in atrophic gastritis may lead to low sensitivity of the routine tests.

Aims. To evaluate the accuracy of routinely used H.pylori tests in atrophic gastritis.

Methods. We compared 5 H.pylori diagnostic tests in 119 dyspeptic patients (28 males/91 females) with a mean age of 67 years (range 55-84). Patients with gastric cancer, peptic ulcer, previous gastric surgery, or those who have received eradication therapy were excluded. The following tests were performed: histology, rapid urease test (RUT), culture, 13C- urease breath tests (UBT), and H.pylori IgG/IgA antibody test (serology).

Results. Atrophic gastritis was diagnosed in 26.1% of the patients; H.pylori was present in 87.1%. In the group with atrophy, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were as follows: histology (100% for all parameters); UBT (96; 100; 100; 80; 97%); serology (96; 50; 93; 67; 90%); culture (96; 100; 100; 80; 97%); and RUT (78; 100; 100; 40; 81%), respectively.

Conclusions.
Histology, UBT and culture were the three best tests for diagnosing H.pylori infection. We cannot recommend using serology as a single test in a case of atrophy, but it would be reasonable to combine serology with one of the above tests.

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Published

2011-12-01

How to Cite

1.
Sudraba A, Daugule I, Rudzite D, Funka K, Tolmanis I, Engstrand L, Janciauskas D, Jonaitis L, Kiudelis G, Kupcinskas L, Ivanauskas A, Leja M. Performance of Routine Helicobacter pylori Tests in Patients with Atrophic Gastritis. JGLD [Internet]. 2011 Dec. 1 [cited 2026 Jul. 16];20(4):349-54. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/2011.4.5

Issue

Vol. 20 No. 4: December 2011

Section

Original Article