Higher Titers of Anti–Saccharomyces Cerevisiae Antibodies IgA and IgG are Associated with More Aggressive Phenotypes in Romanian Patients with Crohn’s Disease

Authors

  • Serban Gologan Department of Gastroenterology and Hepatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Razvan Iacob Department of Gastroenterology and Hepatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Carmen Preda Department of Gastroenterology and Hepatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Roxana Vadan Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania
  • Bogdan Cotruta Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania
  • Ana-Maria Catuneanu Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania
  • Speranta Iacob Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania
  • Ileana Constantinescu Center of Immunogenetics and Virology, Fundeni Clinical Institute, Bucharest, Romania
  • Liana Gheorghe Department of Gastroenterology and Hepatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Silviu Iobagiu 3rd Medical Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Cristian Gheorghe Department of Gastroenterology and Hepatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
  • Mircea Diculescu Department of Gastroenterology and Hepatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

Keywords:

Inflammatory bowel disease, Crohn's disease, phenotype, anti-Saccharomyces cerevisiae antibodies (ASCA)

Abstract

Background & Aims. Serological markers have been widely used for diagnostic purposes and disease stratification in inflammatory bowel diseases (IBD). The aim of this study was to investigate the seroprevalence and the correlations of anti-Saccharomyces cerevisiae antibodies (ASCA) titers with different clinical phenotypes in Romanian patients with Crohn's disease (CD).

Methods. The study included 107 CD and 86 ulcerative colitis (UC) patients from the Gastroenterology Departments of three University Hospitals, and 60 healthy subjects. ASCA IgA and IgG titers were determined using ELISA test. For CD patients the phenotype was established according to the Montreal classification. The differences in ASCA titers for different CD phenotypes were assessed using the Mann-Whitney U test.

Results. ASCA prevalence was 33.6% in CD group, 12.8% in UC group and 6.6% in the control group. Significantly higher IgA (p=0.05) and IgG (p=0.03) titers were found in patients from the Montreal A1+A2 groups (age at onset below 40) compared with the older patients (A3). Higher titers were found in patients with extensive ileo-colonic lesions (L3) and upper gastrointestinal tract involvement (L4) than in patients having only colonic disease (L2). Significantly higher IgA (p=0.03) and IgG (p=0.03) titers were observed in patients with stenosing (B2) and penetrating (B3) disease compared with the nonstricturing, nonpenetrating (B1) phenotype. No correlation between ASCA titers and disease duration was found.

Conclusion. ASCA seropositivity in Romanian CD patients is lower than in Western Europe. Higher ASCA IgA and IgG titers are associated with a younger age at diagnosis and more aggressive phenotypes.

Downloads

Published

2012-03-01

How to Cite

1.
Gologan S, Iacob R, Preda C, Vadan R, Cotruta B, Catuneanu A-M, Iacob S, Constantinescu I, Gheorghe L, Iobagiu S, Gheorghe C, Diculescu M. Higher Titers of Anti–Saccharomyces Cerevisiae Antibodies IgA and IgG are Associated with More Aggressive Phenotypes in Romanian Patients with Crohn’s Disease. JGLD [Internet]. 2012 Mar. 1 [cited 2026 Jul. 19];21(1):39-44. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/2012.1.8

Issue

Vol. 21 No. 1: March 2012

Section

Original Article