Systemic Sclerosis-Polymyositis Overlap Syndrome Associated with Autoimmune Hepatitis and Cerebral Vasculitis

Authors

  • Cristina Pamfil Department of Rheumatology, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Mihnea T. Zdrenghea epartment of Hematology, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Petru A. Mircea 1st Internal Medicine Department, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Roberta M. Manzat Saplacan 1st Internal Medicine Department, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Nicolae Rednic 4th Internal Medicine Department, University of Medicine and Pharmacy, Cluj-Napoca, Romania
  • Simona Rednic Department of Rheumatology, University of Medicine and Pharmacy, Cluj-Napoca, Romania

Keywords:

Systemic sclerosis, scleroderma, autoimmune hepatitis, polymyositis, cerebral vasculitis

Abstract

Autoimmune hepatitis (AIH) is a chronic disorder characterized by persistent hepatocellular inflammation and necrosis. AIH overlap syndromes with other autoimmune diseases have been reported, including connective tissue diseases (CTD). Reports of AIH in systemic sclerosis (SSc), however, are scarce and have been particularly described in the limited SSc subtype. We report a case of systemic sclerosis-polymyositis overlap syndrome that developed AIH and subsequently, cerebral vasculitis. To our knowledge, this is the first report of such a complex mosaic of autoimmunity. We also review the literature regarding scleroderma-related AIH.

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Published

2012-09-01

How to Cite

1.
Pamfil C, Zdrenghea MT, Mircea PA, Manzat Saplacan RM, Rednic N, Rednic S. Systemic Sclerosis-Polymyositis Overlap Syndrome Associated with Autoimmune Hepatitis and Cerebral Vasculitis. JGLD [Internet]. 2012 Sep. 1 [cited 2026 Jul. 16];21(3):317-20. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/2012.3.16

Issue

Vol. 21 No. 3: September 2012

Section

Case Reports