Association of Genetic Polymorphisms in IL17A and IL17F with Gastro-Duodenal Diseases

Authors

  • Ranji Hayashi Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Tomomitsu Tahara Department of Gatroenterology, Fujita Health University, Toyoake, Japan
  • Hisakazu Shiroeda Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Yasuhiro Matsue Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Takahiro Minato Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Tomoe Nomura Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Hideto Yamada Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Takashi Saito Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Kazuhiro Matsunaga Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Tomoki Fukuyama Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Nobuhiko Hayashi Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Toshimi Otsuka Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Atsushi Fukumura Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Masakastu Nakamura Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Mikihiro Tsutsumi Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
  • Tomoyuki Shibata Department of Gatroenterology, Fujita Health University, Toyoake, Japan
  • Tomiyasu Arisawa Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan

Keywords:

Interleukin-17 (IL-17), single nucleotide polymorphism (SNP), gastro-duodenal ulcer, gastric mucosal atrophy, non-steroidal anti-inflammatory drugs (NSAIDs)/aspirin

Abstract

Background & Aim: The important role of IL-17 in inflammatory response to Helicobacter pylori (H. pylori) colonization has been indicated. We investigated the associations between gastro-duodenal diseases and polymorphisms of IL17A (rs2275913 G>A) and IL17F (rs763780 T>C).

Methods: The study was performed in 548 subjects (363 controls and 185 peptic ulcer cases). The multiplex PCR-SSCP method was used to detect gene polymorphisms.

Results: Overall, number of rs2275913 A allele was significantly associated with an increased risk for peptic ulcer (OR, 1.50; 95%CI, 1.11-2.01; p=0.0082). The frequency of rs2275913 GA+AA genotype was also significantly higher in ulcer cases than controls (OR, 1.72; 95%CI, 1.09-2.72; p=0.020). The rs2275913 GA+AA genotype conferred an increased risk for the severity of gastric mucosal atrophy in subjects younger than 60 years (OR, 2.83; 95%CI, 1.14-7.04; p=0.025). Both atrophy and metaplasia were increased with age in rs2275913 GA+AA genotype. In NSAIDs/aspirin users, number of rs2275913 A allele was associated with an increased risk for a peptic ulcer (OR, 3.98; 95%CI, 1.48-10.7; p=0.0061). There was no association of rs763780 with the development of peptic ulcer.

Conclusions: Our results provide the evidence that rs2275913 is associated with an increased risk for peptic ulcer and the severity of the gastric mucosal atrophy in comparatively younger subjects. In addition, this allele is also associated with the increased risk for peptic ulcer in NSAIDs/aspirin users.

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Published

2012-09-01

How to Cite

1.
Hayashi R, Tahara T, Shiroeda H, Matsue Y, Minato T, Nomura T, Yamada H, Saito T, Matsunaga K, Fukuyama T, Hayashi N, Otsuka T, Fukumura A, Nakamura M, Tsutsumi M, Shibata T, Arisawa T. Association of Genetic Polymorphisms in IL17A and IL17F with Gastro-Duodenal Diseases. JGLD [Internet]. 2012 Sep. 1 [cited 2026 Jul. 16];21(3):243-9. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/2012.3.5

Issue

Vol. 21 No. 3: September 2012

Section

Original Article