Metabolic Syndrome, Insulin Resistance, Circadian Disruption, Antioxidants and Pancreatic Carcinoma: an Overview

Authors

  • Aldo Giudice Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale – IRCCS – Naples, Italy
  • Anna Crispo Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale – IRCCS – Naples, Italy
  • Galdiero Massimiliano Department of Experimental Medicine II University of Naples, Italy
  • Giovanni D’Arena Department of Onco- Hematology, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy
  • Mario Felice Tecce Department of Pharmacy, University of Salerno, Italy
  • Maria Grimaldi Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale – IRCCS – Naples, Italy
  • Alfonso Amore Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale – IRCCS, Naples Italy
  • Emanuela Esposito Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale – IRCCS, Naples Italy
  • Maurizio Montella Epidemiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale – IRCCS – Naples, Italy

DOI:

https://doi.org/10.15403/jgld-1282

Keywords:

metabolic syndrome, insulin resistance, circadian disruption, antioxidants, pancreatic cancer

Abstract

The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the incidence and mortality of other common cancers have been declining. Risk factors for this malignant disease include cigarette smoking, family history of chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption and possibly Helicobacter pylori and hepatitis B virus infections. Metabolic diseases have become the leading cause of death in many countries. Our paper serves as a focused and updated discussion about the development of novel preventive strategies for this deadly disease.

Abbreviations. ARE: antioxidant response element; COX-2: cyclooxygenase-2; IGFs: insulin-like growthfactors; IGF1R: IGF-1 receptor; MetS: metabolic syndrome; NAFLD: non-alcoholic fatty liver disease;NAFPD: non-alcoholic fatty pancreas disease; NASH: non-alcoholic steatohepatitis; NASP: non-alcoholic steatopancreatitis; PPARγ : peroxisome proliferator-activated receptor γ; PPARs: peroxisome proliferatoractivated receptors.

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Published

2014-03-01

How to Cite

1.
Giudice A, Crispo A, Massimiliano G, D’Arena G, Tecce MF, Grimaldi M, Amore A, Esposito E, Montella M. Metabolic Syndrome, Insulin Resistance, Circadian Disruption, Antioxidants and Pancreatic Carcinoma: an Overview. JGLD [Internet]. 2014 Mar. 1 [cited 2026 Jul. 16];23(1):73-7. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/2014.1.15

Issue

Vol. 23 No. 1: March 2014

Section

Reviews