Romanian National Guideline on Translating Fecal Microbiota Transplantation Applications related to Clostridioides difficile Infections into the Local Clinical Practice

Authors

  • Georgiana Emmanuela Gilca-Blanariu Grigore T. Popa Univ. of Medicine and Pharmacy, Institute of Gastroenterol and Hepatol, St. Spiridon Univ. Hospital, Iași, Romania
  • Gabriela Stefanescu Grigore T. Popa Univ. of Medicine and Pharmacy, Institute of Gastroenterol and Hepatol, St. Spiridon Univ. Hospital, Iași, Romania
  • Irina Girleanu Grigore T. Popa Univ. of Medicine and Pharmacy, Institute of Gastroenterol and Hepatol, St. Spiridon Univ. Hospital, Iași, Romania
  • Tariq Iqbal University of Birmingham, Birmingham, United Kingdom
  • Jonathan Segal Hillingdon Hospital London, London, United Kingdom
  • Benjamin Mullish Imperial College London, London, United Kingdom
  • Mohammed Nabil Quraishi University of Birmingham, Birmingham, United Kingdom
  • Josbert Keller Depart. of Gastroenterol. Haaglanden Medical Center, The Hague, The Netherlands; Leiden Univ. Medical Center, Leiden, The Netherlands
  • Tamas Molnar Depart. of Internal Medicine, Univ. of Szeged, Szeged, Hungary
  • Francis Megraud Univ. of Bordeaux, Bordeaux, France
  • Dan Dumitrascu Iuliu Hatieganu Univ. of Medicine and Pharmacy, 2 nd Depart. of Internal Medicine, Cluj-Napoca, Romania
  • Mircea Manuc Carol Davila Univ. of Medicine and Pharmacy, Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania
  • Luminita Smaranda Iancu Grigore T. Popa Univ. of Medicine and Pharmacy, Depart. of Microbiology, Iași, Romania
  • Cristina Marica Iuliu Hatieganu Univ. of Medicine and Pharmacy, 2 nd Depart. of Internal Medicine, Cluj-Napoca, Romania
  • Cristian Gheorghe Carol Davila Univ. of Medicine and Pharmacy, Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania
  • Susan Manzoor University of Birmingham, Birmingham, United Kingdom
  • Anca Trifan Grigore T. Popa Univ. of Medicine and Pharmacy, Institute of Gastroenterol and Hepatol, St. Spiridon Univ. Hospital, Iași, Romania

DOI:

https://doi.org/10.15403/jgld-3297

Keywords:

Clostridioides difficile infection, dysbiosis, fecal microbiota transplantation, guideline-stool transplantation

Abstract

Fecal microbiota transplantation involves the infusion of intestinal microorganisms via the transfer of a stool from a healthy individual into a diseased individual, with the intent of restoring normal intestinal flora. Fecal transplant is proposed for the treatment of refractory Clostridioides difficile infection. At present, recurrent Clostridioides difficile infection is the only indication supported by solid scientific evidence. Regulations by healthcare authorities vary among different countries. Considering that Romania does not have an available national guideline to offer standardization, this paper aimed to create a national fecal microbiota transplantation guideline concerning indications, techniques and donor screening, developed by international and local scientific working groups.

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Published

2021-03-13

How to Cite

1.
Gilca-Blanariu GE, Stefanescu G, Girleanu I, Iqbal T, Segal J, Mullish B, Quraishi MN, Keller J, Molnar T, Megraud F, Dumitrascu D, Manuc M, Iancu LS, Marica C, Gheorghe C, Manzoor S, Trifan A. Romanian National Guideline on Translating Fecal Microbiota Transplantation Applications related to Clostridioides difficile Infections into the Local Clinical Practice. JGLD [Internet]. 2021 Mar. 13 [cited 2026 Jun. 15];30(1):147-63. Available from: https://www.jgld.ro/jgld/index.php/jgld/article/view/3297

Issue

Vol. 30 No. 1: March 2021

Section

Romanian SGH corner